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Methods Cigarette smoke extract (CSE) preparation The smoke of one 3R4F Kentucky reference cigarette was bubbled through 7 mL of room temperature PBS

This sets the stage for a future controlled human trial. Reference: Vitamin B12 Supports Skeletal Muscle Oxidative Phosphorylation Capacity in Male Mice by Luisa F Castillo, Katarina E Heyden, Abigail R Williamson, Wenxia Ma, Olga V Malysheva, Nathaniel M Vacanti, Anna E Thalacker-Mercer and Martha S Field, 20 January 2026, The Journal of Nutrition

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